The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors

OBJECTIVE: Based on promising in vitro and in vivo activity of several histone deacetylase inhibitors (HDACi’s) in HL (Hodgkin lymphoma), we investigated SNDX-275, an oral class 1 isoform–selective HDACi in HL-derived cell lines. MATERIALS AND METHODS: Proliferation and cell death were examined by M...

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Autori principali: Jóna, Ádám, Khaskhely, Noor, Buglio, Daniela, Shafer, Jessica A., Derenzini, Enrico, Bollard, Catherine M., Medeiros, L. Jeffrey, Illés, Árpád, Ji, Yuan, Younes, Anas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177003/
https://ncbi.nlm.nih.gov/pubmed/21767511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.07.002
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