Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destruction and respiratory failure primarily in women. LAM is typically caused by tuberous sclerosis complex 2 (TSC2) mutations resulting in mTORC1 activation in proliferative smooth muscle–like cells in the lung...

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Bibliografiske detaljer
Main Authors: Li, Chenggang, Lee, Po-Shun, Sun, Yang, Gu, Xiaoxiao, Zhang, Erik, Guo, Yanan, Wu, Chin-Lee, Auricchio, Neil, Priolo, Carmen, Li, Jing, Csibi, Alfredo, Parkhitko, Andrey, Morrison, Tasha, Planaguma, Anna, Kazani, Shamsah, Israel, Elliot, Xu, Kai-Feng, Henske, Elizabeth Petri, Blenis, John, Levy, Bruce D., Kwiatkowski, David, Yu, Jane J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892971/
https://ncbi.nlm.nih.gov/pubmed/24395886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131080
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