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Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

The severe acute respiratory syndrome (SARS) pandemic revealed that zoonotic transmission of animal coronaviruses (CoV) to humans poses a significant threat to public health and warrants surveillance and the development of countermeasures. The activity of host cell proteases, which cleave and activa...

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Detalhes bibliográficos
Main Authors: Simmons, Graham, Zmora, Pawel, Gierer, Stefanie, Heurich, Adeline, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889862/
https://ncbi.nlm.nih.gov/pubmed/24121034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2013.09.028
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