Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion

Severe acute respiratory syndrome coronavirus (SARS-CoV) poses a considerable threat to human health. Activation of the viral spike (S)-protein by host cell proteases is essential for viral infectivity. However, the cleavage sites in SARS-S and the protease(s) activating SARS-S are incompletely defi...

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Main Authors: Simmons, Graham, Bertram, Stephanie, Glowacka, Ilona, Steffen, Imke, Chaipan, Chawaree, Agudelo, Juliet, Lu, Kai, Rennekamp, Andrew J., Hofmann, Heike, Bates, Paul, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086175/
https://ncbi.nlm.nih.gov/pubmed/21435673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.02.020
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