Highly Conserved Regions within the Spike Proteins of Human Coronaviruses 229E and NL63 Determine Recognition of Their Respective Cellular Receptors

We have recently demonstrated that the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor angiotensin converting enzyme 2 (ACE2) also mediates cellular entry of the newly discovered human coronavirus (hCoV) NL63. Here, we show that expression of DC-SIGN augments NL63 spike (S)-protein...

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Detalhes bibliográficos
Main Authors: Hofmann, Heike, Simmons, Graham, Rennekamp, Andrew J., Chaipan, Chawaree, Gramberg, Thomas, Heck, Elke, Geier, Martina, Wegele, Anja, Marzi, Andrea, Bates, Paul, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563880/
https://ncbi.nlm.nih.gov/pubmed/16912312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00560-06
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