Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

BACKGROUND: Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis to RA. P gingivalis is apparently unique among periodontal pathogens in possessing a citrullinating enzyme, peptidylargini...

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Autores principales: Quirke, Anne-Marie, Lugli, Elena Birgitta, Wegner, Natalia, Hamilton, Bart C, Charles, Peter, Chowdhury, Muslima, Ytterberg, A Jimmy, Zubarev, Roman A, Potempa, Jan, Culshaw, Shauna, Guo, Yonghua, Fisher, Benjamin A, Thiele, Geoffrey, Mikuls, Ted R, Venables, Patrick JW
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2014
Materias:
Basic and Translational Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888615/
https://ncbi.nlm.nih.gov/pubmed/23463691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-202726
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