Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?

Peptidylarginine deiminases (PADs) convert arginine within a peptide (peptidylarginine) into peptidylcitrulline. Citrullination by human PADs is important in normal physiology and inflammation. Porphyromonas gingivalis, a major pathogen in periodontitis, is the only prokaryote described to possess P...

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Bibliographic Details
Main Authors: Mangat, Pamela, Wegner, Natalia, Venables, Patrick J, Potempa, Jan
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911857/
https://ncbi.nlm.nih.gov/pubmed/20553633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3000
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