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pVHL-Mediated Transcriptional Repression of c-Myc by Recruitment of Histone Deacetylases
The biological functions of Myc are to regulate cell growth, apoptosis, cell differentiation and stem-cell self-renewal. Abnormal accumulation of c-Myc is able to induce excessive proliferation of normal cells. von Hippel-Lindau protein (pVHL) is a key regulator of hypoxia-inducible factor1α (HIF1α)...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Korea Society for Molecular and Cellular Biology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887712/ https://ncbi.nlm.nih.gov/pubmed/22286234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-012-2268-3 |
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