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Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3
Transforming growth factor-β (TGF-β) inhibits osteoblast differentiation through inhibition of the function of Runx2 (Cbfa1) by Smad3. The mechanism through which TGF-β/Smad3 inhibits Runx2 function has not been characterized. We show that TGF-β induces histone deacetylation, primarily of histone H4...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1176457/ https://ncbi.nlm.nih.gov/pubmed/15990875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600729 |
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