The c-FLIP(L) Cleavage Product p43FLIP Promotes Activation of Extracellular Signal-regulated Kinase (ERK), Nuclear Factor κB (NF-κB), and Caspase-8 and T Cell Survival

Caspase-8 is now appreciated to govern both apoptosis following death receptor ligation and cell survival and growth via inhibition of the Ripoptosome. Cells must therefore carefully regulate the high level of caspase-8 activity during apoptosis versus the modest levels observed during cell growth....

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Bibliographische Detailangaben
Hauptverfasser: Koenig, Andreas, Buskiewicz, Iwona A., Fortner, Karen A., Russell, Jennifer Q., Asaoka, Tomoko, He, You-Wen, Hakem, Razqallah, Eriksson, John E., Budd, Ralph C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887185/
https://ncbi.nlm.nih.gov/pubmed/24275659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506428
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