Caspase-8 and c-FLIP(L) Associate in Lipid Rafts with NF-κB Adaptors during T Cell Activation

Humans and mice lacking functional caspase-8 in T cells manifest a profound immunodeficiency syndrome due to defective T cell antigen receptor (TCR)-induced NF-κB signaling and proliferation. It is unknown how caspase-8 is activated following T cell stimulation, and what is the caspase-8 substrate(s...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Misra, Ravi S., Russell, Jennifer Q., Koenig, Andreas, Hinshaw-Makepeace, Jennifer A., Wen, Renren, Wang, Demin, Huo, Hairong, Littman, Dan R., Ferch, Uta, Ruland, Jurgen, Thome, Margot, Budd, Ralph C.
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521413/
https://ncbi.nlm.nih.gov/pubmed/17462996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M610610200
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