Cyclic GMP-AMP Synthase is Activated by Double-stranded DNA-Induced Oligomerization

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide 2′,5′ cGAMP that binds to STING and mediates the activation of TBK1 and IRF-3. Activated IRF-3 translocates to the nucleus and initiates...

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Main Authors: Li, Xin, Shu, Chang, Yi, Guanghui, Chaton, Catherine T., Shelton, Catherine L., Diao, Jiasheng, Zuo, Xiaobing, Kao, C Cheng, Herr, Andrew B., Li, Pingwei
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886715/
https://ncbi.nlm.nih.gov/pubmed/24332030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.10.019
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