Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these events remains unclear. Here, using an array of...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Abdisalaam, Salim, Bhattacharya, Souparno, Mukherjee, Shibani, Sinha, Debapriya, Srinivasan, Kalayarasan, Zhu, Mingrui, Akbay, Esra A., Sadek, Hesham A., Shay, Jerry W., Asaithamby, Aroumougame
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415994/
https://ncbi.nlm.nih.gov/pubmed/32540968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012962
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