Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these events remains unclear. Here, using an array of...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Abdisalaam, Salim, Bhattacharya, Souparno, Mukherjee, Shibani, Sinha, Debapriya, Srinivasan, Kalayarasan, Zhu, Mingrui, Akbay, Esra A., Sadek, Hesham A., Shay, Jerry W., Asaithamby, Aroumougame
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Cell Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415994/
https://ncbi.nlm.nih.gov/pubmed/32540968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012962
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