Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these events remains unclear. Here, using an array of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Abdisalaam, Salim, Bhattacharya, Souparno, Mukherjee, Shibani, Sinha, Debapriya, Srinivasan, Kalayarasan, Zhu, Mingrui, Akbay, Esra A., Sadek, Hesham A., Shay, Jerry W., Asaithamby, Aroumougame
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415994/
https://ncbi.nlm.nih.gov/pubmed/32540968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012962
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