Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these events remains unclear. Here, using an array of...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Abdisalaam, Salim, Bhattacharya, Souparno, Mukherjee, Shibani, Sinha, Debapriya, Srinivasan, Kalayarasan, Zhu, Mingrui, Akbay, Esra A., Sadek, Hesham A., Shay, Jerry W., Asaithamby, Aroumougame
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415994/
https://ncbi.nlm.nih.gov/pubmed/32540968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012962
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