Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these events remains unclear. Here, using an array of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Abdisalaam, Salim, Bhattacharya, Souparno, Mukherjee, Shibani, Sinha, Debapriya, Srinivasan, Kalayarasan, Zhu, Mingrui, Akbay, Esra A., Sadek, Hesham A., Shay, Jerry W., Asaithamby, Aroumougame
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415994/
https://ncbi.nlm.nih.gov/pubmed/32540968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012962
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