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Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
TREX1 is an exonuclease that digests DNA in the cytoplasm. Loss-of-function mutations of TREX1 are linked to Aicardi–Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE) in humans. Trex1(−/−) mice exhibit autoimmune and inflammatory phenotypes that are associated with elevated expression...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4620884/ https://ncbi.nlm.nih.gov/pubmed/26371324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516465112 |
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