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Cyclic GMP-AMP Synthase is an Innate Immune Sensor of HIV and Other Retroviruses
Retroviruses, including HIV, can activate innate immune responses, but the host sensors for retroviruses are largely unknown. Here we show that HIV infection activates cyclic-GMP-AMP (cGAMP) synthase (cGAS) to produce cGAMP, which binds to and activates the adaptor protein STING to induce type-I int...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3860819/ https://ncbi.nlm.nih.gov/pubmed/23929945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1240933 |
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