Cyclic GMP-AMP Synthase (cGAS) Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Activation of the DNA-dependent cytosolic surveillance pathway in response to Mycobacterium tuberculosis infection stimulates ubiquitin-dependent autophagy and inflammatory cytokine production, and plays an important role in host defense against M. tuberculosis. However, the identity of the host sen...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Collins, Angela C., Cai, Haocheng, Li, Tuo, Franco, Luis H., Li, Xiao-Dong, Nair, Vidhya R., Scharn, Caitlyn R., Stamm, Chelsea E., Levine, Beth, Chen, Zhijian J, Shiloh, Michael U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499468/
https://ncbi.nlm.nih.gov/pubmed/26048137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.05.005
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