SMN is essential for the biogenesis of U7 snRNP and 3′-end formation of histone mRNAs

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by a deficiency in the survival motor neuron (SMN) protein. SMN mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs) and possibly other RNPs. Here we investigated SMN requirement for the biogenesis and fun...

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Main Authors: Tisdale, Sarah, Lotti, Francesco, Saieva, Luciano, Van Meerbeke, James P., Crawford, Thomas O., Sumner, Charlotte J., Mentis, George Z., Pellizzoni, Livio
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885245/
https://ncbi.nlm.nih.gov/pubmed/24332368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.012
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