SMN is essential for the biogenesis of U7 snRNP and 3′-end formation of histone mRNAs

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by a deficiency in the survival motor neuron (SMN) protein. SMN mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs) and possibly other RNPs. Here we investigated SMN requirement for the biogenesis and fun...

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Detalhes bibliográficos
Main Authors: Tisdale, Sarah, Lotti, Francesco, Saieva, Luciano, Van Meerbeke, James P., Crawford, Thomas O., Sumner, Charlotte J., Mentis, George Z., Pellizzoni, Livio
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885245/
https://ncbi.nlm.nih.gov/pubmed/24332368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.012
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