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Neurodegenerative diseases and widespread aggregation are associated with supersaturated proteins

The maintenance of protein solubility is a fundamental aspect of protein homeostasis, as aggregation is associated with cytotoxicity and a variety of human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold and aggregate, and widespread aggregation can occur in liv...

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מידע ביבליוגרפי
Main Authors: Ciryam, Prajwal, Tartaglia, Gian Gaetano, Morimoto, Richard I., Dobson, Christopher M., Vendruscolo, Michele
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883113/
https://ncbi.nlm.nih.gov/pubmed/24183671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.043
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