Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

Amyotrophic lateral sclerosis (ALS) is a heterogeneous degenerative motor neuron disease linked to numerous genetic mutations in apparently unrelated proteins. These proteins, including SOD1, TDP-43, and FUS, are highly aggregation-prone and form a variety of intracellular inclusion bodies that are...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Ciryam, Prajwal, Lambert-Smith, Isabella A., Bean, Daniel M., Freer, Rosie, Cid, Fernando, Tartaglia, Gian Gaetano, Saunders, Darren N., Wilson, Mark R., Oliver, Stephen G., Morimoto, Richard I., Dobson, Christopher M., Vendruscolo, Michele, Favrin, Giorgio, Yerbury, Justin J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441770/
https://ncbi.nlm.nih.gov/pubmed/28396410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613854114
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