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Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor
We introduce the term ‘silent agonists’ to describe ligands that can place the α7 nicotinic acetylcholine receptor (nAChR) into a desensitized state with little or no apparent activation of the ion channel, forming a complex that can subsequently generate currents when treated with an allosteric mod...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3882203/ https://ncbi.nlm.nih.gov/pubmed/23746476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.039 |
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