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Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
Cbls are RING ubiquitin ligases that attenuate receptor tyrosine kinase (RTK) signal transduction. Cbl ubiquitination activity is stimulated by phosphorylation of a linker helix region (LHR) tyrosine residue. To elucidate the mechanism of activation, we determined structures of human CBL, a CBL–subs...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880865/ https://ncbi.nlm.nih.gov/pubmed/22266821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2231 |
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