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Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity
MDM2-MDMX complexes bind the p53 tumor suppressor protein, inhibiting p53’s transcriptional activity and targeting p53 for proteasomal degradation. Inhibitors that disrupt binding between p53 and MDM2 efficiently activate a p53 response although their use in the treatment of cancers that retain wild...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6205632/ https://ncbi.nlm.nih.gov/pubmed/28553961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3414 |
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