Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice

The MDM2 RING domain harbors E3 ubiquitin ligase activity critical for regulating the degradation of tumor suppressor p53, which controls many cellular pathways. The MDM2 RING domain also is required for an interaction with MDMX. Mice containing a substitution in the MDM2 RING domain, MDM2(C462A), d...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Tian, Hui, Tackmann, Nicole R., Jin, Aiwen, Zheng, Junnian, Zhang, Yanping
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766955/
https://ncbi.nlm.nih.gov/pubmed/29123033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000122
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