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Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice
The MDM2 RING domain harbors E3 ubiquitin ligase activity critical for regulating the degradation of tumor suppressor p53, which controls many cellular pathways. The MDM2 RING domain also is required for an interaction with MDMX. Mice containing a substitution in the MDM2 RING domain, MDM2(C462A), d...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766955/ https://ncbi.nlm.nih.gov/pubmed/29123033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000122 |
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