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Mdm2 targets the p53 transcription cofactor JMY for degradation
We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells. At a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1796743/ https://ncbi.nlm.nih.gov/pubmed/17170761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400855 |
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