Mdm2 targets the p53 transcription cofactor JMY for degradation

We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells. At a...

Full description

Saved in:
Bibliographic Details
Main Authors: Coutts, Amanda S, Boulahbel, Houda, Graham, Anne, La Thangue, Nicholas B
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Scientific Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1796743/
https://ncbi.nlm.nih.gov/pubmed/17170761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400855
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items