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Structure of BIRC7–E2 ubiquitin conjugate reveals the mechanism of ubiquitin transfer by a RING dimer

RING ubiquitin ligases (E3s) recruit E2 thioesterified with Ub to facilitate Ub transfer to a target. Certain RING E3s dimerize to form active ligases but structural evidence on how this process promotes Ub transfer is lacking. Several members of the baculovirus inhibitor of apoptosis repeat-contain...

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Detalhes bibliográficos
Main Authors: Dou, Hao, Buetow, Lori, Sibbet, Gary J., Cameron, Kenneth, Huang, Danny T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880866/
https://ncbi.nlm.nih.gov/pubmed/22902369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2379
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