E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis

Casitas B-lineage lymphoma (CBL) is a ubiquitin ligase (E3) that becomes activated upon Tyr371-phosphorylation and targets receptor protein tyrosine kinases for ubiquitin-mediated degradation. Deregulation of CBL and its E3 activity is observed in myeloproliferative neoplasms and other cancers, incl...

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Bibliographic Details
Published in:Oncogene
Main Authors: Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads, Lilla, Sergio, Sibbet, Gary J., Sumpton, David, Zanivan, Sara, Hedley, Ann, Clark, William, Huang, Danny T.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994203/
https://ncbi.nlm.nih.gov/pubmed/33627783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01684-x
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