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Direct determination of haplotypes from single DNA molecules

Determining the long-range haplotypes in a diploid individual is a major technical challenge. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual human DNA molecules simultaneously. We demonstrate the utility of this technology by accurately...

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Bibliografski detalji
Glavni autori: Xiao, Ming, Wan, Eunice, Chu, Catherine, Hsueh, Wen-Chi, Cao, Yang, Kwok, Pui-Yan
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880790/
https://ncbi.nlm.nih.gov/pubmed/19198595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1301
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