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Direct determination of haplotypes from single DNA molecules
Determining the long-range haplotypes in a diploid individual is a major technical challenge. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual human DNA molecules simultaneously. We demonstrate the utility of this technology by accurately...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880790/ https://ncbi.nlm.nih.gov/pubmed/19198595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1301 |
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