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Tackling the widespread and critical impact of batch effects in high-throughput data

High-throughput technologies are widely used, for example to assay genetic variants, gene and protein expression, and epigenetic modifications. One often overlooked complication with such studies is batch effects, which occur because measurements are affected by laboratory conditions, reagent lots a...

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Detalhes bibliográficos
Main Authors: Leek, Jeffrey T., Scharpf, Robert B., Bravo, Héctor Corrada, Simcha, David, Langmead, Benjamin, Johnson, W. Evan, Geman, Donald, Baggerly, Keith, Irizarry, Rafael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880143/
https://ncbi.nlm.nih.gov/pubmed/20838408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg2825
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