Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.

To study the involvement of cyclin D1 in epithelial growth and differentiation and its putative role as an oncogene in skin, transgenic mice were developed carrying the human cyclin D1 gene driven by a bovine keratin 5 promoter. As expected, all squamous epithelia including skin, oral mucosa, trache...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Robles, A I, Larcher, F, Whalin, R B, Murillas, R, Richie, E, Gimenez-Conti, I B, Jorcano, J L, Conti, C J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755527/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.7634
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