Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.

To study the involvement of cyclin D1 in epithelial growth and differentiation and its putative role as an oncogene in skin, transgenic mice were developed carrying the human cyclin D1 gene driven by a bovine keratin 5 promoter. As expected, all squamous epithelia including skin, oral mucosa, trache...

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Main Authors: Robles, A I, Larcher, F, Whalin, R B, Murillas, R, Richie, E, Gimenez-Conti, I B, Jorcano, J L, Conti, C J
格式: Artigo
語言:Inglês
出版: 1996
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC38798/
https://ncbi.nlm.nih.gov/pubmed/8755527
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