A Xanthine-Derivative K(+)-Channel Opener Protects against Serotonin-Induced Cardiomyocyte Hypertrophy via the Modulation of Protein Kinases

This study investigated whether KMUP-1, a xanthine-derivative K(+) channel opener, could prevent serotonin-induced hypertrophy in H9c2 cardiomyocytes via L-type Ca(2+) channels (LTCCs). Rat heart-derived H9c2 cells were incubated with serotonin (10 μM) for 4 days. The cell size increased by 155.5%,...

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Detalhes bibliográficos
Main Authors: Kuo, Hsuan-Fu, Lai, Yan-Jie, Wu, Jung-Chou, Lee, Kun-Tai, Chu, Chih-Sheng, Chen, Ing-Jun, Wu, Jiunn-Ren, Wu, Bin-Nan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879592/
https://ncbi.nlm.nih.gov/pubmed/24391452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.7894
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