A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle

1. KMUP-1 (1, 3, 5 mg kg(−1), i.v.), a xanthine derivative, produced dose-dependent sustained hypotensive and short-acting bradycardiac effects in anaesthetized rats. This hypotensive effect was inhibited by pretreatment with glibenclamide (5 mg kg(−1), i.v.). 2. In endothelium-intact or denuded aor...

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Bibliographische Detailangaben
Hauptverfasser: Wu, Bin-Nan, Lin, Rong-Jyh, Lin, Chiu-Yin, Shen, Kuo-Pyng, Chiang, Lien-Chai, Chen, Ing-Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2001
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572942/
https://ncbi.nlm.nih.gov/pubmed/11564644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704231
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