KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K(+) channels

1. In isolated endothelium-intact or denuded rabbit corpus cavernosum preconstricted with phenylephrine, KMUP-1 (0.001 – 10 μM) caused a concentration-dependent relaxation. 2. This relaxation of KMUP-1 was attenuated by endothelium removed, high K(+) and pretreatments with a soluble guanylyl cyclase...

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Detalhes bibliográficos
Main Authors: Lin, Rong-Jyh, Wu, Bin-Nan, Lo, Yi-Ching, Shen, Kuo-Pyng, Lin, Young-Tso, Huang, Chun-Hsiung, Chen, Ing-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573218/
https://ncbi.nlm.nih.gov/pubmed/11877322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704554
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