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KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K(+) channels
1. 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) produces tracheal relaxation, intracellular accumulation of cyclic nucleotides, inhibition of phosphodiesterases (PDEs) and activation of K(+) channels. 2. KMUP-1 (0.01–100 μM) induced concentration-dependent relaxation resp...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2004
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1575170/ https://ncbi.nlm.nih.gov/pubmed/15237094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705791 |
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