The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K(+)-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries

Serotonin (5-hydroxytryptamine, 5-HT) is a potent pulmonary vasoconstrictor that promotes pulmonary artery smooth muscle cell (PASMC) proliferation. 5-HT-induced K(+) channel inhibition increases [Ca(2+)](i) in PASMCs, which is a major trigger for pulmonary vasoconstriction and development of pulmon...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Biol Sci
Hauptverfasser: Dai, Zen-Kong, Liu, Yu-Wei, Hsu, Jong-Hau, Yeh, Jwu-Lai, Chen, Ing-Jun, Wu, Jiunn-Ren, Wu, Bin-Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440253/
https://ncbi.nlm.nih.gov/pubmed/25999786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.11127
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