The DNA Methyltransferase Dnmt1 Directly Interacts with the SET and RING Finger-associated (SRA) Domain of the Multifunctional Protein Uhrf1 to Facilitate Accession of the Catalytic Center to Hemi-methylated DNA

Dnmt1 is responsible for the maintenance DNA methylation during replication to propagate methylation patterns to the next generation. The replication foci targeting sequence (RFTS), which plugs the catalytic pocket, is necessary for recruitment of Dnmt1 to the replication site. In the present study...

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Main Authors: Berkyurek, Ahmet Can, Suetake, Isao, Arita, Kyohei, Takeshita, Kohei, Nakagawa, Atsushi, Shirakawa, Masahiro, Tajima, Shoji
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
DNA and Chromosomes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879560/
https://ncbi.nlm.nih.gov/pubmed/24253042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523209
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