Metabolism of 2,2′,3,3′,6,6′-Hexachlorobiphenyl (PCB 136) Atropisomers in Tissue Slices from Phenobarbital or Dexamethasone-Induced Rats is Sex-Dependent

1. Chiral polychlorinated biphenyls (PCBs) such as PCB 136 enantioselectively sensitize the ryanodine receptor (RyR). In light of recent evidence that PCBs cause developmental neurotoxicity via RyR-dependent mechanisms, this suggests that enantioselective PCB metabolism may influence the development...

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Detalhes bibliográficos
Main Authors: Wu, Xianai, Kania-Korwel, Izabela, Chen, Hao, Stamou, Marianna, Dammanahalli, Karigowda J., Duffel, Michael, Lein, Pamela J., Lehmler, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878182/
https://ncbi.nlm.nih.gov/pubmed/23581876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2013.785626
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