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Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation
T-cell large granular lymphocytic (T-LGL) leukemia is a clonal disease characterized by the expansion of mature CD3+CD8+ cytotoxic T cells. It is often associated with autoimmune disorders and immune-mediated cytopenias. Our recent findings suggest that up to 40% of T-LGL patients harbor mutations i...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3877422/ https://ncbi.nlm.nih.gov/pubmed/24317090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.65 |
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