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Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
Aromatase catalyzes the conversion of testosterone to estradiol and is the main source of endogenous estrogen in postmenopausal women. Aromatase inhibitors (AIs) are used to treat postmenopausal women with hormone receptor–positive breast cancer. Norendoxifen [4-(1-(4-(2-aminoethoxy)phenyl)-2-phenyl...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876808/ https://ncbi.nlm.nih.gov/pubmed/23824607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052506 |
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