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Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
Aromatase catalyzes the conversion of testosterone to estradiol and is the main source of endogenous estrogen in postmenopausal women. Aromatase inhibitors (AIs) are used to treat postmenopausal women with hormone receptor–positive breast cancer. Norendoxifen [4-(1-(4-(2-aminoethoxy)phenyl)-2-phenyl...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876808/ https://ncbi.nlm.nih.gov/pubmed/23824607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052506 |
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