Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

ACE (angiotensin-1-converting enzyme) is a zinc metallopeptidase that plays a prominent role in blood pressure regulation and electrolyte homeostasis. ACE consists of two homologous domains that despite similarities of sequence and topology display differences in substrate processing and inhibitor b...

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Détails bibliographiques
Auteurs principaux: Douglas, Ross G., Sharma, Rajni K., Masuyer, Geoffrey, Lubbe, Lizelle, Zamora, Ismael, Acharya, K. Ravi, Chibale, Kelly, Sturrock, Edward D.
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2013
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875237/
https://ncbi.nlm.nih.gov/pubmed/24015848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20130403
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