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Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors
ACE (angiotensin-1-converting enzyme) is a zinc metallopeptidase that plays a prominent role in blood pressure regulation and electrolyte homeostasis. ACE consists of two homologous domains that despite similarities of sequence and topology display differences in substrate processing and inhibitor b...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Portland Press Ltd.
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3875237/ https://ncbi.nlm.nih.gov/pubmed/24015848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20130403 |
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