Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen

BACKGROUND: HIV-1 Nef is a viral accessory protein critical for AIDS progression. Nef lacks intrinsic catalytic activity and binds multiple host cell signaling proteins, including Hck and other Src-family tyrosine kinases. Nef binding induces constitutive Hck activation that may contribute to HIV pa...

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Bibliografiska uppgifter
Huvudupphovsmän: Trible, Ronald P, Narute, Purushottam, Emert-Sedlak, Lori A, Alvarado, John Jeff, Atkins, Katelyn, Thomas, Laurel, Kodama, Toshiaki, Yanamala, Naveena, Korotchenko, Vasiliy, Day, Billy W, Thomas, Gary, Smithgall, Thomas E
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2013
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874621/
https://ncbi.nlm.nih.gov/pubmed/24229420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-135
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