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Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner
The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell proteins, including specific members of the Src kinase family. Here we explored whether Src-family kinase activation is a conserved property of Nef...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290594/ https://ncbi.nlm.nih.gov/pubmed/22393415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032561 |
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