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HIV-1 Nef Dimerization is required for Nef-Mediated Receptor Downregulation and Viral Replication
Nef, an HIV-1 accessory factor capable of interaction with a diverse array of host cell signaling molecules, is essential for high-titer HIV replication and AIDS progression. Previous biochemical and structural studies have suggested that Nef may form homodimers and higher order oligomers in HIV-inf...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783173/ https://ncbi.nlm.nih.gov/pubmed/19781555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.09.047 |
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