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The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner

The HIV-1 Nef virulence factor interacts with multiple host cell-signaling proteins. Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation important for viral infectivity, replication, and MHC-I down-regulation. Itk and other Tec family kinases are also presen...

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Sonraí Bibleagrafaíochta
Main Authors: Tarafdar, Sreya, Poe, Jerrod A., Smithgall, Thomas E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140925/
https://ncbi.nlm.nih.gov/pubmed/24722985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572099
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