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Synthesis and Structure-activity Analysis of Diphenylpyrazolodiazene Inhibitors of the HIV-1 Nef Virulence Factor

HIV-1 Nef is a critical AIDS progression factor yet underexplored target for antiretroviral drug discovery. A recent high-throughput screen for pharmacological inhibitors of Nef-dependent Src-family kinase activation identified a diphenylpyrazolodiazene hit compound with submicromolar potency in HIV...

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Detalhes bibliográficos
Main Authors: Iyer, Prema C., Zhao, Jielu, Emert-Sedlak, Lori A., Moore, Kerry, Smithgall, Thomas E., Day, Billy W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990189/
https://ncbi.nlm.nih.gov/pubmed/24650642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.02.045
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